A Convenient Method for Calculating the Median Lethal Dose in Toxicity Testing

Computer program calculating median lethal dose of drugs

药物半数致死量的计算程序

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Median lethal time, mean lifespan and mean maximum lifespan of drosophila fed with different concentration of ponceau 4R were lower than those in control groups dominantly ( P < 0.05 or P < 0.01) in survival experiment, and a dose-response relationship was shown.

生存试验中各浓度组雌雄果蝇的半数死亡时间、平均寿命及平均最高寿命均较对照组缩短（P<0.05或P<0.01），且存在剂量-反应关系。

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The median lethal time ( LT50) of the GV was shortened with the increase of the virus concentration and the decrease of the larval instar, during which the GV was fed.

幼虫饲毒后，致死中时（LT（50））随病毒浓度提高而缩短；随饲毒时虫龄的增大而延长。

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The median lethal time ( LT_ ( 50)) of P_ ( f) NPV to the larvae was shortened with the increase of the viral concentration.

各测试浓度下致死中时间（LT（50）为3.43-5.14天，随病毒浓度提高而缩短。

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The most virulent strain was screened out after evaluated by the indices of mortality, infection rate and the median lethal time ( LT50).

以桃蚜的校正死亡率、感染率及致死中时（LT（50））为指标综合评价不同菌株毒力。

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Conclusion Nano-hydroxyapatite has no accumulative toxicity to rabbits, it is suggested that it is safe when the hydroxyapatite-sol was applied intravenously as a drug carrier in small dosage more less than the medium lethal dose, even as a kind of anticancer drug.

结论纳米HAP在家兔无明显蓄积毒性，提示当用量远远小于最小致死剂量时，纳米HAP可作为药物载体，甚至在将来可能作为一种新型的抗癌药物，经静脉安全应用。

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The oral acute toxicity test showed LD50 ( medium lethal dose)> 5.5 g/ Kg. Such result demonstrates that the synthesized product is nontoxic according to the classification of acute toxicity standard.

通过对合成的产物进行急性经口毒性试验，发现其经口半数致死量（LD50，medium lethal dose）大于5.5g/Kg，按照急性毒性分级标准确定该依布硒林衍生物属实际无毒级。

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The reasonable time of ultraviolet radiation treatment to urediospores of Chinese wheat yellow rust race 29 ( CY29-3) is the time of 90% relative percentage of lethality of urediospores. The 88.97% relative percentage of lethality of urediospore was gotten after 8 minutes ultraviolet radiation treatment.

以夏孢子相对致死率90%左右作为紫外线处理最适时间，发现8min为小麦条锈菌条中29号单孢菌系（CY29-3）最适处理时间，其夏孢子相对致死率达88.97%。

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The ultra-structural changes of Monopterus albus liver cells were observed with transmission electron microscopy after sublethal exposure to Cu2+ and nonionic surfactant AE ( linear alkylethoxylate).

利用透射电镜研究了亚致死浓度的Cu2+或表面活性剂AE（脂肪醇聚氧乙烯醚）对黄鳝肝细胞结构的损伤作用。

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CONCLUSION: With the increase of HIFU irritation time, the survival rate of tumor cells presents the linear decrease tendency. And 1 000 W/ cm2 × 30 seconds is the minimum dose of bringing cells into complete dead and breaking them into debris.

结论：当高强度聚焦超声声强固定为1000W/cm2时，细胞存活率随高强度聚焦超声辐照时间延长呈直线下降，1000W/cm2×30s是能灭活肿瘤细胞且使之完全破碎的剂量。

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Conclusion: The minimum dose of active DNA to induce SLE-like syndrome was 10^ tg, and it predominantly evoked the humoral response.

结论：10腭活性DNA即可诱导小鼠SLE样综合征，主要诱导自身体液免疫应答。

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The elaboratively-designed treatment plan is capable of having the tumor receive higher dose level while the normal tissues and organs receive minimum dose level.

结果表明，精心设计的治疗计划能使肿瘤区域接受到高的治疗剂量，而周围正常组织和器官接受的剂量最少。

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It was the better way to use the mid dose CF combined with the minimum dose 5 Fu in the treatment of advanced colonic cancer.

中剂量醛氢叶酸与小剂量氟脲嘧啶是治疗晚期肠癌的较好组合。

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The minimum dose of N. gonorrhoeae which can be detected by ELISA was 1 × 10 4 bacteria per ml.

淋球菌的最小检测量为1×104个／ml。

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Minimum dose of protection of recombinant pseudorabies virus ( rPRV-GP5) against pseudorabies in sheep

重组伪狂犬病毒（rPRV-GP5）对伪狂犬病最小免疫剂量的测定

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Objective To probe the minimum dose for trial diagnostic radiation of suspected intracranial germinoma.

目的探讨拟诊颅内生殖细胞瘤试验性放疗的最低剂量。

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The results showed that the minimal lethal dose of Norfloxacin to embryos is 320mg/ kg embryo weight, and the lethal dose 50% ( LD60) for 3-day-old chicks 4 985+ 753.18 tag/ kg body weight.

结果表明，氟哌酸对鸡胚的最小致死剂量为320mg/kg胚重；对3日龄雏鸡的LD（50）为4985±753.18mg/kg体重。

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Methods: To carry out external bacteriostasis experiment first by the method of drilling hole, then To definite minimal lethal dose by preliminary test, finally to do internal bacteriostasis experiment with mice.

方法：先采用打孔法进行体外抑菌试验，然后通过预试验找到最小致死浓度，最后用小白鼠进行体内抑菌试验。

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Protection mechanism of mice transferred by AAV 2-BPI_ ( 700)-Fc γ 1_ ( 700) recombinant virus to minimal lethal dose E.coli infection

AAV2-BPI（700）-Fcγ1（700）重组病毒导入小鼠对致死量大肠埃希菌感染的保护作用机制

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Objective To observe the resistance of mice that were transfected with BPI_700-Fc γ 1_700 chimera gene to minimal lethal dose ( MLD) of E.

目的通过观测BPI700-Fcγ1700嵌合基因导入小鼠对最小致死量E。

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