Objective: To study the clinical significances of expressions of ER 、 PR 、 nm23 and P53 in bilateral primary breast cancer ( BPBC) and clinically and pathologically analyse 55 cases with the lesions.

1、

Results: 1.The overall 5-year, 10-year survival rates ( life table method) of the whole group, the synchronous BPBC group were 71.4%, 50.9%; 56.7%, 44.4%, respectively.

结果：1、全组5年和10年总生存率（寿命表法）分别为71.4%和50.9%，同时性癌依次为66.7%、44.4%；

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2、

Methods The clinical data of 222 patients with BPBC, admitted to Tianjin Medical University Cancer Institute and Hospital from March 1972 to December 2003 were collected and analyzed on prognosis factors.

方法对天津市医科大学附属肿瘤医院1972年3月~2003年12月收治的222名BPBC患者的临床资料进行预后因素分析。

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3、

Conclusions: 1. The main risk factors of BPBC may be once having breast cancer, familial history of breast cancers, etc.

结论：1、患一侧乳腺癌、有乳腺癌家族史等是发生双侧乳腺癌的重要危险因素。

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4、

Otherwise, in the environment of the corpus borderism, interpose the key steps id how to control the A/ D switch with the SCM in details.

另外，在汇编语言环境下，利用单片机控制A/D转换的关键步骤和详细编程过程也作了介绍。

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5、

By analyses, the main reason of poor reservoir heterogeneity is the change of depositional environment.

综合分析认为, 引起储层非均质性的主要原因是沉积环境的变化.

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6、

Undetected changes in raw materials specifications, or subtle changes in manufacturing procedures, may affect the stability of BPCs.

原料质量标准中未发现的变化，或制造工艺中微小的差别，可能会影响原料的稳定性。

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7、

Mother liquors containing recoverable amounts of BPCs are frequently re-used.

包含可回收原料药的母液通常可以再次使用。

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8、

Three areas in the processing of finished batches of BPCs should be examined carefully and critically.

最后原料药的处理中的三个区域应仔细并关键检查。

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9、

Adequate sanitation of buildings and areas for BPCs requires considerable judgement.

建筑物和原料药的区域的充分消毒需要相当的鉴定。

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10、

Ensure the match between Raw Material actual storage and the quantity in BPCS.

确保原材料实际库存与BPCS系统里面的数据相吻合；

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11、

Purified water is widely used in the manufacture of BPCs.

纯化水广泛地用于原料药的制造中。

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12、

Certain type of Generator Control Unit ( GCU) and Bus Power Control Unit ( BPCU) are two newly developed products.

某型号发电机控制器与汇流条功率控制器是新近研制的产品。

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13、

The changes of 8-OH-dG in the progress of carcinogenesis were detected in human bronchial epithelial cells induced by Benzo ( a) pyrene diol-epoxide ( BPDE) and sulfide nickel ( NiS) in vitro.

并利用苯并（a）芘代谢产物B（a）P二醇环氧化物（BPDE）和结晶型硫化镍（NiS）诱导的体外人支气管上皮细胞转化癌变模型，检测癌变进程中8OH dG的变化。

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14、

The tumor was squamose carcinoma confirmed by histopathological examination. The culture system in this study provided a potential tool for studying the molecular mechanism of carcinogenesis of human bronchial epithelial cells induced by BPDE.

本实验以反式BPDE成功地诱发了人支气管上皮细胞恶性转化，为后期进一步研究其致癌的分子机制、寻找致癌相关基因提供了理想的生物学材料。

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The content increase of 8-OH-dG was in accordance with the progress of cell carcinogenesis, which was displayed in human bronchial epithelial cells induced by BPDE and NiS.

在体外用BPDE和NiS作用于人支气管上皮细胞系诱导其转化和癌变过程中，8OH dG出现于细胞转化之前，其含量的增加与细胞癌变进程相一致。

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16、

Conclusions Anti-BPDE can result in DNA strand breakage, and the degrees of damage is related to the administrated doses of anti BPDE.

结论反式BPDE可导致DNA断裂损伤，其损伤程度与剂量有一定关系。

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Mutation induced by ￣( 60) Co γ-ray BPDE in msu-1 · 1 human fibroblast at the HPRT locus

~（60）Coγ射线和BPDE诱发人成纤维细胞hprt基因突变的研究

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18、

A comparative study on mutation by γ-radiation and BPDE was conducted in MSU-1 · 1 human fibroblasts at the hprt gene.

对γ射线和BPDE诱发人成纤维细胞株MSU－1·1bprt基因突变进行了比较研究。

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19、

Methods A549 cells cultured in vitro were divided into heat stress group and BPDE group.

方法体外培养的A549细胞分为高温应激组和BPDE组。

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BPDM is not yet a standard.

BPDM还未成为一个标准。

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