anergic

As professional type 1 interferon-producing cells, Pre-DC2 have a capacity to induce an anergic state in human T cell lines.

作为体内主要的Ⅰ型干扰素（IFN）分泌细胞，Pre-DC2还具有诱导T细胞无反应性的能力。

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And determined the proliferation of anergic T cells response to exogenous IL-2 and different doses of SEA.

并测定无能T细胞对加大SEA剂量和外源性IL-2的应答反应。

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These results suggest that ability of proliferation of CD4+ T cell gradually decrease which restrain the response to the second stimulation and is in anergic state.

结论：CD4~+T细胞在SEB刺激后虽有增埴，但增殖后的CD4~+T细胞的增殖能力逐渐下降，对二次抗原刺激增殖受抑，即处于无能状态；

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Conclusion: The activation and proliferation of naive T cells could be induced by SEA singly, and the T cells became anergic by repeated SEA induction in vitro.

结论：SEA初次诱导小鼠脾淋巴细胞时，能显著促进T细胞的活化和增殖；经SEA多次刺激（3次）可诱导T细胞的无反应性。

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The anergic state of T cells was not limited by doses of SEA and there were other causes on anergic state of T cells excepting IL-2.

T细胞无反应性不受SEA剂量限制，T细胞受抗原刺激不能产生IL-2不是无能状态产生的唯一原因。

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Anergic cells were phenotypically analyzed by the flow cytometry.

流式细胞仪检测无能细胞的表型。

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The responsiveness of anergic T cells could be restored gradually after some times.

但体内外诱导的无能T细胞经过一段时间的休息，其应答反应是可以逐渐恢复的。

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In vivo, faint responsiveness of anergic T cells induced by SEA injections at 3 days interval and at 28 days interval could be seen respectively after 21 days and 28 days.

在体内，间隔3天组和间隔28天组中诱导的无能T细胞分别从末次注射后第21天和第28天开始出现较弱的应答反应。

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The ability of anergic cells to respond to antigen and/ or exogenous recombinant mouse interleukin-2 ( rmIL-2) was tested.

无能细胞中加入刺激抗原或重组小鼠IL-2（rmIL-2），观察无能细胞的反应情况。

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