Clinical research of treatment with tumor specific cytotoxic T lymphocyte in patients with carcinoma

The Detection of Cytotoxic T Lymphocyte about its Activity and its Application

细胞毒性T淋巴细胞活性的检测及应用

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Result: B7-1 gene modified tumor cells can stimulate splenocyte growth apparently. Vaccination with allicin and MBT-2 B 7 · 1 generated the strongest cytotoxic lymphocyte responses to parental MBT-2 tumor cells.

结果：B7.1转基因肿瘤疫苗能有效刺激淋巴细胞增殖。当B7·1转基因肿瘤疫苗与大蒜素联合应用时，具有最大的抗肿瘤效果。

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Objective To investigate the role of soluble form of cytotoxic lymphocyte associated antigen-4 CTLA-4 ( sCTLA-4) in the pathogenesis of atopic asthma.

目的探讨血清可溶性细胞毒T淋巴细胞相关抗原-4（sCTLA-4）在哮喘发病机制中的作用。

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Objective To investigate the specific induction of cytotoxic lymphocyte ( CTL) by tumor derived heat shock protein 90 peptide complexes ( HSP90 PC).

目的探讨肿瘤组织来源的热休克蛋白90肽复合物（HSP90PC）诱导产生特异性细胞毒性T淋巴细胞（CTL）的作用。

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Objective To study the biological characters of cytotoxic lymphocyte ( CTL) transduced with TNF-α gene.

目的：构建TNFα基因转染的CTL，并对其生物学特性进行研究。

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The cytotoxic effect of antitumor drug on Hep-2 cell was achieved by inducing apoptosis.

对人喉癌Hep-2细胞的细胞毒作用主要是通过诱导凋亡实现的。

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This study was designed to investigate anti tumor effects of differentiation inducing agent in combination with cytotoxic chemotherapeutic drug against glioma.

本研究旨在探讨诱导分化剂与细胞毒化疗药抗胶质瘤的联合效应。

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There is comparability but no statistical significance in the basic clinical data in each group.3.Chemo-therapeutical schedule: the same schedule was adopted ( the third generation cytotoxic drug combined with Platinum), namely paclitaxel plus cisplatin. 4.

两组患者基本临床资料具有可比性，无统计学意义。（3）化疗方案：采用相同的化疗方案（第三代细胞毒药物联合铂类）即顺铂联合紫杉醇。

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The primary goal of the strategy is to selectively increase tumor cell exposure to cytotoxic drug metabolites generated locally by a prodrug-activating P450 enzyme, which expresses highly in tumor cells after being transduced.

这种方法的首要目标就是选择性地使细胞色素P450在肿瘤细胞内超量表达。

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OBJECTIVE: To investigate the effect of bayberry polyphenol ( BPP) on thrombopenia induced by cytotoxic drug and radiation in mice and rats.

目的：研究杨梅多酚对大、小白鼠在化学和辐射损伤中血小板减少的影响。

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Objective: To reveal the synergistic antiangiogenic effects and mechanisms of novel recombinant human endostatin ( Endostar) combined with cytotoxic drug cisplatin.

目的：揭示新型重组人内皮抑素（Endostar，恩度）与细胞毒药物顺铂联合使用的抗血管形成作用，探讨联合用药方式产生协同作用的分子机制。

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Objective: Chemical medicines for traditional cancer therapy are mostly Cytotoxic drug, which have defect of severe side effect, low selectivity and easy to cause drug-resistance.

目的：传统治疗肿瘤的化疗药物以细胞毒类药物为主，其毒副作用大、选择性低和易产生抗药性。

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Methods: The antitumor effect of the therapeutic lipopeptide vaccine against cervical cancer by interferon-γ at the different concentration was investigated by cytotoxic test. The expression of HLA-A2 and CD54 on the tumor cell was detected by flow cytometry.

方法：采用细胞毒性试验观察不同剂量γ干扰素对宫颈癌治疗性脂肽疫苗的抗肿瘤作用的影响，采用流式细胞术检测宫颈癌细胞HLA-A2分子和CD54的表达。

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In cytotoxic test by MTT method, there are 2,4,12 samples ′ inhibition rate to KB, Raji and Hep G2 respectively higher than 50% in 25 μ g/ mL.

在细胞毒实验中，分别有2个、4个和12个样品在浓度为25μg/mL时，对KB细胞、Raji细胞和Hep G2细胞的抑制率高于50%；

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Safety evaluation of AMX-LH-NEThe safety of AMX-LH-NE was evaluated in vivo and in vitro by acute toxicity test, skin irritation test and cytotoxic test of mammary epithelial cells.

AMX-LH-NE的安全性评价通过急性毒性试验、皮肤刺激性试验和乳腺上皮细胞毒性试验，对AMX-LH-NE进行体内外安全性评价。

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Method: The vacuolated effect and its relationship to VacA of H.pylori clinical isolates were investigated by the method of cytotoxic test 、 SDS-PAGE and scan.

方法：用细胞毒试验、SDS-PAGE结合薄层扫描研究H.pylori临床分离株空泡毒作用及其与VacA的关系。

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Methods All the 747 patients with un-definition rheumatic diseases were detected HLA-B_ 27 by standard NIH micro-lymphocyte cytotoxic test.

方法采用标准NIH微量淋巴细胞毒实验方法对747例临床诊断不确定风湿性疾病患者做HLA-B27抗原检测。

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Methods First, HA-contain bioceramic toxic tests including generalized toxic test, skin stimulation test, hemolytic test, Ames test and cytotoxic test were carried out.

方法首先将含羟基磷灰石生物陶瓷进行毒性试验，包括全身毒性试验、皮肤刺激试验、溶血试验、Ames试验及细胞毒性试验。

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Method: The antiviral effects of this drug were observed by cytotoxic test on Hep-2 cells and direct antiviral test in vitro.

方法：采用细胞毒性试验，体外直接抗病毒试验观察本品的抗病毒作用。

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Studies on Characteristics of Macrophage-derived Cytotoxic Factor

巨噬细胞细胞毒因子性质的研究

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